Spacey is due to appear at London’s Westminster Magistrates Court on Thursday.
The alleged incidents took place in London between March 2005 and August 2008, and one in western England in April 2013. The victims are now in their 30s and 40s.
The Crown Prosecution Service authorized charges against Spacey last month.
Spacey, a double Academy Award winner, was questioned by the British police in 2019 about claims by several men that he had assaulted them. The former “House of Cards” star ran London’s Old Vic theater between 2004 and 2015.
Spacey won a best supporting actor Academy Award for the 1995 film “The Usual Suspects” and a lead actor Oscar for the 1999 movie “American Beauty.”
But his career came to abrupt halt in 2017 when actor Anthony Rapp was accused of being a star of assaulting him in the 1980s, when Rapp was a teenager. Spacey denies the allegations.